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Associate .mat Files with MATLAB

To associate a .mat extension type with MATLAB®, use Microsoft® Windows® Default Programs. For information about using this option, see your Windows documentation.

By default, MATLAB associates the latest installed version to MATLAB file types. However, once you use the Windows Control Panel or the file manager to associate a MATLAB version to a file type, you must manually re-associate the type with each new installation of MATLAB. If you want to return to the default behavior, then uninstall every MATLAB that is manually associated to any MATLAB file type. Then reinstall the latest MATLAB release.