imfill small but not big holes

Hello!

I'm interested in measuring the area of the "bigger holes" in the middle of this image. Does anyone have an idea of how can I fill the smaller holes without filling the bigger ones? Is there any way to specify the size of the holes that you want to fill?

Thanks in advanced.

Maria

[Rik]

You could use imfill to fill all holes, then compare with your original image to find all holes themselves, and loop (or arrayfun) through all holes to determine with regionprops which holes shouldn't have been filled.