SimBiology provides a set of integrated apps that are designed to facilitate building, simulating, and analyzing models of dynamic systems such as quantitative systems pharmacology (QSP), pharmacokinetic/pharmacodynamic (PK/PD) and systems biology models.
The SimBiology app lets you build dynamic models interactively using various modeling elements. For instance, you can model a variety of biological systems such as signaling pathways, metabolic networks, PBPK, QSP, and PK/PD models. It also lets you model biological variability and different dosing regimens to investigate various experimental conditions and dosing strategies.
The SimBiology Model Analyzer app lets you perform analyses on models of dynamic systems. You can simulate the dynamic behavior of a model using various solvers and estimate model parameters. To investigate system dynamics and guide experimentation, you can perform sensitivity analysis and parameter sweeps.
This example shows how to create and simulate a simple model of receptor-ligand kinetics using the SimBiology app and SimBiology Model Analyzer app.
The SimBiology app provides three different views of a model: the Diagram view, Table view, and Equations view.
Copy and paste SimBiology blocks while building models in the Diagram.
The SimBiology app provides keyboard shortcuts for various modeling actions.
Perform noncompartmental analysis and calibrate model parameters by fitting to experimental PKPD data using nonlinear regression.
Perform sensitivity analysis to find important model parameters.
Generate sample values for model parameters to represent virtual patients and simulate to explore model variability.
Explore multiple dosing amounts that meets the efficacy and toxicity thresholds.