How can Simbiology dosing be administered continuously instead of discretely?
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MathWorks Support Team
on 12 Jul 2017
Edited: MathWorks Support Team
on 18 Apr 2024
How can dosing be administered continuously instead of discretely?
Here is what I am currently trying:
-Start the Simbiology App
-Add a Linear {Clearance, Volume} Infusion Model
-Add a "schedule dose" to the model under "Dose_Central"
-Double click green table next to 'dose_1'
-Click "Editor..." button
I am unsure of how to specify the dosage so that it is continuous instead of providing a discrete amount at each time. I have looked through some documentation on dosing but was unclear if there was an easy way to change the 'rate' to accomplish this.
Accepted Answer
MathWorks Support Team
on 18 Apr 2024
Edited: MathWorks Support Team
on 18 Apr 2024
There are two ways to implement continuous dosing:
1) Use a repeat or scheduled dose with just one dose starting at t=0. You can set the 'rate' parameter to the rate you need and set the 'amount' parameter to a large number. This way, the total amount will never be reached and the dose is given continuously. Your 'amount' should be larger than 'rate*(duration of simulation)'
2) Instead of a dose object you can introduce a reaction “null -> species” reaction with a rate parameter k and mass action kinetics. This describes a continuous synthesis or dosing of “species”.
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