Is there a listing of functions (such as 'trapz') to use in SimBiology explorer?

I am looking to generate some standard PK parameters from the simulation runs (AUC, Tmax, Cmax etc).

Is there a listing of functions somewhere that I can incorporate into the explorer such as 'trapz'?

Answer 1

[Sietse Braakman]

Hi Andrew,

You could use the following:

Cmax: max(Central.Drug_Central)

Tmax: time(Central.Drug_Central == max(Central.Drug_Central))

Tend: time(end)

AUC0-last: trapz(time,Central.Drug_Central)

Other quantities (half-life, C0, AUC0-inf, CL etc) require extrapolation and regressions, which is what sbionca takes care of for you. More definitions of the NCA parameters are here.

You could also turn your simulation results into a table and pass that onto sbionca. This is somewhat easier said then done. I have some code that you download here, see the function 'CreateTableSimdata' in the NCA folder of the download.

Let me know if you have further questions.

Best,

Sietse

[Andrew Heitman]

This looks great. Is it possible to build the data table creation and sbionca command into a custom task?