Presynaptic Mapping

Calculation and Monte-Carlo simulation of probabilities associated with cell-type distributions

This folder contains Matlab functions for calculations and Monte-Carlo-simulations of probabilities associated with the distribution of cell types within a cluster of cells, based on the null-hypothesis that these cells are randomly drawn from a pool of cells with known cell-type distribution.
The functions have been applied to analyze cell-type distributions of ganglion cells within presynaptic clusters resulting from single-cell initiated rabies tracing in LGN:

"Different Modes of Visual Integration in the Lateral Geniculate Nucleus Revealed by Single-Cell-Initiated Transsynaptic Tracing", Santiago B. Rompani, Fiona E. Müllner, Adrian Wanner, Chi Zhang, Chiara N. Roth, Keisuke Yonehara, Botond Roska. Neuron , Volume 93 , Issue 4 , 767 - 776.e6, DOI: http://dx.doi.org/10.1016/j.neuron.2017.01.028