In Silico Medicine

Use Computational Modelling and Simulation (CM&S) to design, test, and validate medical devices

In silico medicine is the use of computational models and simulations to develop medical devices. With MATLAB and Simulink for medical device R&D, you can: 

  • Speed up development and reduce costs by enabling virtual prototyping and testing
  • Improve safety and efficacy of medical devices via early feasibility studies with simulations
  • Provide supportive regulatory evidence from computational modeling and simulation (CM&S) studies for medical device approvals

“Being able to see the full development, from a blank canvas to the physical thing that will go into clinical trials, in 40 days was fantastic.”

Max Curzi, senior software engineer at Cambridge Consultants

Speed Up Product Development and Reduce Costs

In silico medicine significantly speeds up the design process and reduces costs in medical device R&D by enabling virtual prototyping and testing through computational models. This approach minimizes the need for expensive physical prototypes and early-stage clinical trials. You can identify potential design flaws or failures early in the development process, allowing for quicker iterations and cost savings.

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In Silico Medicine for Modelling and Simulation of Medical Devices

Improve Medical Device Safety and Efficacy

In silico medicine improves the safety and efficacy of medical devices by enabling thorough safety testing and efficacy evaluation through computational modeling and simulation. These simulations can identify potential safety risks and adverse effects, as well as provide early indications of how effectively a medical device diagnoses or treats a condition. This means you can refine the product design early in the development process and focus on the most promising configurations for clinical trials.

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A Simulink model of a medical ventilator using in silico medicine.
Designing a ventilator in 47 days using Model-Based Design.

Provide Supportive Evidence for Regulatory Approvals

In silico medicine can support regulatory submissions for medical device approvals by providing comprehensive device performance validations, risk assessments, and outcomes from in silico clinical trials. The simulation-based data complement traditional clinical data, showcasing device safety and efficacy, particularly in personalized medicine contexts with different patient populations.

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FDA regulatory guidelines for medical devices using in silico medicine.
Successes and opportunities in modeling and simulation for FDA.

In Silico Medicine Model Examples

Get started with MATLAB and Simulink for in silico medicine using the example models below.

In silico medicine example model of a medical ventilator and lungs.

Medical Ventilator Model in Simscape

This example shows a positive airway pressure (PAP) medical ventilator system with a lung model. It provides a starting point for designers working on medical ventilators and PAP devices.

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In silico medicine example model of an ECMO/heart-lung machine and cardiovascular system.

Cardiovascular System in Simscape with ECMO Machine

The cardiovascular model lets you simulate the flows and pressures of the human cardiovascular system. You can use the model for the development of ECMO machines and heart-lung machines.

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In silico medicine example model of an artificial pancreas and a diabetic patient.

Artificial Pancreas Using Fuzzy Logic Controller

This example shows you how to design and optimize a fuzzy inference system (FIS) tree to control an artificial pancreas. You can use the model in the development of continuous glucose monitoring (CGM) systems and insulin pumps.

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In silico medicine example model of a dialysis machine and a kidney.

Dialysis Machine in Simulink

This model shows an ultrafiltration control system for a hemodialysis machine with Simulink and Stateflow. You can use the model in the development of dialysis machines.

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In silico medicine example model of an infusion pump and blood stream.

Model-Based Design and Verification for Infusion Pump

This model shows an infusion pump with a control system for the flow. You can use it in the verification and validation of infusion pumps and other safety-critical medical devices.

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In silico medicine example model of an electrophysiological heart with a pacemaker.

Electrophysiological Heart Model with Pacemaker in Simulink

This model shows an electrophysiological heart with a pacemaker in Simulink. You can use the model in the development of pacemakers and other cardiac rhythm management (CRM) devices with closed-loop testing

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Build Your Startup with MATLAB and Simulink

See how other startups use MATLAB.

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How In Silico Medicine Can Accelerate Innovation in Medical Devices

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