It depends which "port" you mean, and it probably depends on which model you want to use.
For example the Vivid 910 has no serial ports, but it does have a SCSI II port, and it probably arrives with device drivers that allow programs to communicate with the scanner.
I have designed direct SCSI device drivers in the past, and they have not been hard to program, especially if you are comfortable building table-driven state-machine type software. Though, just as is the case for any kind of device one might build a driver for, devices with SCSI interfaces might mis-handle particular interface commands, or might have bugs in the device, so some level of trail-and-error and reprogramming is to be expected if you write a device driver for a SCSI device.
Note: you pretty much need to write in C or equivalent to program a device driver yourself. MATLAB does not offer any SCSI interface toolkit.
