extremely noise image, what are some techniques I could use to de-noise?

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Inside the blue is what I want to keep. Problem is, it's so blurry that things like gaussian filters and adaptive noise-removal filtering are of no use. What are some other method I could try? I'd appeciate any help I can get!

Accepted Answer

Image Analyst
Image Analyst on 8 Aug 2017
Read this comprehensive overview of noise reduction methods by one of the leaders in the denoising field: https://users.soe.ucsc.edu/~milanfar/publications/journal/ModernTour.pdf

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