Constraint optimization for an unknown relation between objective function and variables

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Hi All,
I want to do a constraint optimization for in the following way.
I have two contraint variables, lets call them d -diameter and Youngs modulus - E. (d, E are constraint within certain limits)
I want to minimize the stress- "S" induced in the structure depending on "d" and "E".I do not have a direct relationship of S with "d" and "E". I have a big computational model with many functions and scripts. For a specific set of d and E it returns me S.
For eg. the code setup is as follows:
function [S] = optimize(d,E)
...
...
... FEM model (quite big)....
...
S = 10log10(Incident Load (d,E)/Transmitted Load(d,E));
% Incident Load depends on d,E but this relationship is not known and too complicated to know.
% Transmitted Load depends on d,E but this relationship is not known and too complicated to know.
end
I am quite a beginner in to use optimization toolbox but all the exmaples I found were having a relationship defined between S and (d,E). Can someone guide me to a proper documentation for these kind of problems??
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