Interactive 2-D Hexagonal Map

I am trying to map out a series of images (which contain sites that are in a hexagonal packing structure) and monitor any changes between the images. Essentially, I am trying to create a ‘interactive hexagonal map’ where I can change the label on each site by clicking and export the position/label information.

My vision is to create a GUI where I can click on a hexagonal tile to change its color to indicate a certain state of the site at that location, and then save/export the data/image. I would do this with each image in the series, after which I would perform an analysis on the activity of the site over time..but that's another journey.

I have found several examples of making hexagonal grids, like meshgrid() and even Self Organizing Maps, but I am not sure about which direction would be most fruitful. Any suggestions?