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Hello,

In this task I'm trying to generate six matrices (m_plot_I, h_plot_I, m_plot_E, h_plot_E, Ge and Gi). The for loop is very simple: as time t passes, the same formula gets performed over and over until we hit niter - 1. I'm quite sure there's a way to make this code more efficient with vectorization, however I can't get my head around this. Could you help me? Thanks!

G_max_chl = 20; % Maximal conductance of chloride

G_max_glu = 30; % Maximal conductance of glutamate

Vm = -70:10:0; % Array of holding potentials

tau_rise_In = 0.15; % Tau rise for inhibition

tau_decay_In = 0.5; % Tau decay for inhibition

tau_rise_Ex = 0.23; % Tau rise for excitation

tau_decay_Ex = 0.7; % Tau decay for excitation

tmax = 15; % Duration of experiment

EGlu = 0; % Reversal potential of glutamate

EChl = -70; % Reversal potential of chloride

% Initialize time

t = 0; % Start

dt = 0.1; % time step duration (ms)

% Total number of time steps in the experiment:

niter = ceil(tmax/dt);

% Initialize values

m_plot_I = zeros(1,niter);

h_plot_I = zeros(1,niter);

m_plot_E = zeros(1,niter);

h_plot_E = zeros(1,niter);

Ge = zeros(1,niter);

Gi = zeros(1,niter);

for ii = 1: niter-1 % For each of the time steps

% Update gating variables for inhibition

m_plot_I(1,ii) = 1 - exp(-t / tau_rise_In); % Activation

h_plot_I(1,ii) = exp(-t / tau_decay_In); % Inactivation

% Update gating variables for excitation

m_plot_E(1,ii) = 1 - exp(-t / tau_rise_Ex); % Activation

h_plot_E(1,ii) = exp(-t / tau_decay_Ex); % Inactivation

% Update conductances

Gi(1,ii) = G_max_chl * (1 - exp(-t / tau_rise_In)) * (exp(-t / tau_decay_In)); % Inhibitory

Ge(1,ii) = G_max_glu * (1 - exp(-t / tau_rise_Ex)) * (exp(-t / tau_decay_Ex)); % Excitatory

t = t+0.1;

end

Alan Stevens
on 8 Feb 2021

Try the following:

G_max_chl = 20; % Maximal conductance of chloride

G_max_glu = 30; % Maximal conductance of glutamate

Vm = -70:10:0; % Array of holding potentials

tau_rise_In = 0.15; % Tau rise for inhibition

tau_decay_In = 0.5; % Tau decay for inhibition

tau_rise_Ex = 0.23; % Tau rise for excitation

tau_decay_Ex = 0.7; % Tau decay for excitation

tmax = 15; % Duration of experiment

EGlu = 0; % Reversal potential of glutamate

EChl = -70; % Reversal potential of chloride

% Initialize time

dt = 0.1; % time step duration (ms)

t = 0:dt:tmax;

% Total number of time steps in the experiment:

niter = ceil(tmax/dt);

% Update gating variables for inhibition

m_plot_I = 1 - exp(-t / tau_rise_In); % Activation

h_plot_I = exp(-t / tau_decay_In); % Inactivation

% Update gating variables for excitation

m_plot_E = 1 - exp(-t / tau_rise_Ex); % Activation

h_plot_E = exp(-t / tau_decay_Ex); % Inactivation

% Update conductances

Gi = G_max_chl * (1 - exp(-t / tau_rise_In)) .* (exp(-t / tau_decay_In)); % Inhibitory

Ge = G_max_glu * (1 - exp(-t / tau_rise_Ex)) .* (exp(-t / tau_decay_Ex)); % Excitatory

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