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SimBiology Model Analyzer の Fit Data タスクを実行すると、 Integration Tolerance Not Met のエラーが発生します。回避方法を教えてください。 kA031000000TCuvCAG 000068315

I am running a Fit Data task in Simbiology for a two step model: L + A <---> LA LA + BG <---> C The reaction rate for the two reactions are respectively: kon1*A*L - koff1*LA kon2*LA*BG - koff2*C I am using the concentration of C as my independent / response variable and time as my dependent / predictor variable to estimate the parameter "kon2"; the other three parameters are known. Every time I run the simulation, I get the following error: Integration Tolerance Not Met I have tried changing i) the initial value of "kon2", ii) the tolerance and number of iterations, and iii) the solver used to estimate the parameter, to no avail. What could be causing this error and how can I resolve this? kA031000000TCuvCAG 000068315

I can't seem to find the answer to my question in SimBiology's documentation. Does anyone know how Matlab calculates the non-compartmental AUC? Does it use the linear / log-linear trapezoidal rule? How many points does it use to extrapolate the curve to infinity? Does it use log or linear extension? Many thanks!